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Gefitinib has an interesting development history and has contributed greatly to our understanding of the biology of NSCLC and the role of the EGF-R signalling pathways.

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Randomised comparison of combination chemotherapy plus supportive care with supportive care alone in patients with metastatic colorectal cancer.

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In contrast, the exchange of glycine (G) for cysteine (C) at codons 12 and 13 and valine (V) at codon 12 increased the level of GTP-bound KRAS up to 2-fold, indicating that the identity of the replacing amino acid determines the GTPase activity of oncogenic KRAS, with aspartic acid (D) having the least effect.

HER2 low-expressing gastric cancer cell lines (GCIY, MKN-28, MKN-45, MKN-74) were resistant to gefitinib with IC 50 more than 10 μ M (), indicating a correlation between degree of HER2 expression and gefitinib sensitivity in gastric cancer cell lines.

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Given the approved therapeutic target for gefitinib, further work was conducted to compare the distribution of gefitinib in LoVo with two lung-derived xenografts, A549 and Calu-6.

The second and third deletions were associated with the insertion of a serine residue, resulting from the generation of a novel codon at the deletion breakpoint.

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The use of vitamin and mineral supplements was associated with improved survival in multivariate analyses among patients with both SCLC and NSCLC.

NSCLC) cell lines were assessed by using MTT, bromide assay, flow cytometry, anchorage-independent growth, coimmunoprecipitation, and Western blot analysis.

IV NSCLC treated with cisplatin-vinorelbine chemotherapy plus cetuximab or chemotherapy alone.

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Therasse P, Arbuck SG, Eisenhauer EA, Wanders J, Kaplan RS, Rubinstein L, Verweij J, Van Glabbeke M, van Oosterom AT, Christian MC, Gwyther SG: New guidelines to evaluate the response to treatment in solid tumors.

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Gaikwad A, Wolf JK, Brown J, Ramondetta LM, Smith JA: In vitro evaluation of the effects of gefitinib on the cytotoxic activity of selected anticancer agents in a panel of human endometrial cancer cell lines.

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