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LTRAs -- sold under the brand names Accolate by AstraZeneca and Singulair by Merck -- have long been on the market as an alternative to steroid inhalers commonly used by asthmatics.

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In addition to Trial 1 and Trial 2, the safety and efficacy of the individual components, mometasone furoate MDI 100 mcg and 200 mcg, in comparison to placebo were demonstrated in three other, 12-week, placebo controlled trials which evaluated the mean change in FEV 1 from baseline as a primary endpoint.

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