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What is the mechanism of action of colchicine quizlet? What is the mechanism of action of colchicine ? Colchicine binds to tubulin inhibiting its polymerizatio and preventing the formation of microtubules. This disrupts cellular functions, such as the mobility of granulocytes, thus decreasing their migration into the affected area.
Does colchicine reduce uric acid levels? Low doses of colchicine can be taken every day to reduce the tendency for attacks. However, this will not get rid of crystals or prevent long-term joint damage because colchicine does not reduce the levels of uric acid in the blood. These drugs increase the amount of uric acid that is removed from the body in urine.
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